Treatment of Breast Cancer-Related Lymphedema with Adipose-Derived Regenerative Cells and Fat Grafts: A Feasibility and Safety Study.
Identifieur interne : 000057 ( Main/Exploration ); précédent : 000056; suivant : 000058Treatment of Breast Cancer-Related Lymphedema with Adipose-Derived Regenerative Cells and Fat Grafts: A Feasibility and Safety Study.
Auteurs : Navid Mohamadpour Toyserkani [Danemark] ; Charlotte Harken Jensen [Danemark] ; Ditte Caroline Andersen [Danemark] ; S Ren Paludan Sheikh [Danemark] ; Jens Ahm S Rensen [Danemark]Source :
- Stem cells translational medicine [ 2157-6564 ] ; 2017.
Abstract
Breast cancer-related lymphedema (BCRL) is a debilitating late complication with a lack of treatment opportunities. Recent studies have suggested that mesenchymal stromal cells can alleviate lymphedema. Herein, we report the results from the first human pilot study with freshly isolated adipose-derived regenerative cells (ADRC) for treating lymphedema with 6 months follow-up. Ten BCRL patients were included. ADRC was injected directly into the axillary region, which was combined with a scar-releasing fat graft procedure. Primary endpoints were change in arm volume. Secondary endpoints were change in patient reported outcome and safety. The study is registered with ClinicalTrials.gov (NCT02592213). During follow-up, a small volume reduction was noted but was not significant. Five patients reduced their use of conservative management. Patient-reported outcomes improved significantly over time. ADRCs were well tolerated and only minor transient adverse events related to liposuction were noted. In this pilot study, a single injection of ADRC improved lymphedema based on patient-reported outcome measures, and there were no serious adverse events in the 6 months follow-up period. In addition, half of the patients reduced their use of conservative management. ADRC therapy is a promising interventional therapy for alleviating lymphedema, but results need to be confirmed in randomized clinical trials. Stem Cells Translational Medicine 2017;6:1666-1672.
DOI: 10.1002/sctm.17-0037
PubMed: 28653440
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000126
- to stream PubMed, to step Curation: 000126
- to stream PubMed, to step Checkpoint: 000126
- to stream Ncbi, to step Merge: 009225
- to stream Ncbi, to step Curation: 009225
- to stream Ncbi, to step Checkpoint: 009225
- to stream Main, to step Merge: 000057
- to stream Main, to step Curation: 000057
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Treatment of Breast Cancer-Related Lymphedema with Adipose-Derived Regenerative Cells and Fat Grafts: A Feasibility and Safety Study.</title><author><name sortKey="Toyserkani, Navid Mohamadpour" sort="Toyserkani, Navid Mohamadpour" uniqKey="Toyserkani N" first="Navid Mohamadpour" last="Toyserkani">Navid Mohamadpour Toyserkani</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Plastic Surgery, Odense University Hospital, Odense, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Departments of Plastic Surgery, Odense University Hospital, Odense</wicri:regionArea><wicri:noRegion>Odense</wicri:noRegion></affiliation></author><author><name sortKey="Jensen, Charlotte Harken" sort="Jensen, Charlotte Harken" uniqKey="Jensen C" first="Charlotte Harken" last="Jensen">Charlotte Harken Jensen</name><affiliation wicri:level="1"><nlm:affiliation>The Danish Centre for Regenerative Medicine, Odense University Hospital, Odense, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>The Danish Centre for Regenerative Medicine, Odense University Hospital, Odense</wicri:regionArea><wicri:noRegion>Odense</wicri:noRegion></affiliation></author><author><name sortKey="Andersen, Ditte Caroline" sort="Andersen, Ditte Caroline" uniqKey="Andersen D" first="Ditte Caroline" last="Andersen">Ditte Caroline Andersen</name><affiliation wicri:level="1"><nlm:affiliation>The Danish Centre for Regenerative Medicine, Odense University Hospital, Odense, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>The Danish Centre for Regenerative Medicine, Odense University Hospital, Odense</wicri:regionArea><wicri:noRegion>Odense</wicri:noRegion></affiliation></author><author><name sortKey="Sheikh, S Ren Paludan" sort="Sheikh, S Ren Paludan" uniqKey="Sheikh S" first="S Ren Paludan" last="Sheikh">S Ren Paludan Sheikh</name><affiliation wicri:level="1"><nlm:affiliation>The Danish Centre for Regenerative Medicine, Odense University Hospital, Odense, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>The Danish Centre for Regenerative Medicine, Odense University Hospital, Odense</wicri:regionArea><wicri:noRegion>Odense</wicri:noRegion></affiliation></author><author><name sortKey="S Rensen, Jens Ahm" sort="S Rensen, Jens Ahm" uniqKey="S Rensen J" first="Jens Ahm" last="S Rensen">Jens Ahm S Rensen</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Plastic Surgery, Odense University Hospital, Odense, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Departments of Plastic Surgery, Odense University Hospital, Odense</wicri:regionArea><wicri:noRegion>Odense</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28653440</idno><idno type="pmid">28653440</idno><idno type="doi">10.1002/sctm.17-0037</idno><idno type="wicri:Area/PubMed/Corpus">000126</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000126</idno><idno type="wicri:Area/PubMed/Curation">000126</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000126</idno><idno type="wicri:Area/PubMed/Checkpoint">000126</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000126</idno><idno type="wicri:Area/Ncbi/Merge">009225</idno><idno type="wicri:Area/Ncbi/Curation">009225</idno><idno type="wicri:Area/Ncbi/Checkpoint">009225</idno><idno type="wicri:doubleKey">2157-6564:2017:Toyserkani N:treatment:of:breast</idno><idno type="wicri:Area/Main/Merge">000057</idno><idno type="wicri:Area/Main/Curation">000057</idno><idno type="wicri:Area/Main/Exploration">000057</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Treatment of Breast Cancer-Related Lymphedema with Adipose-Derived Regenerative Cells and Fat Grafts: A Feasibility and Safety Study.</title><author><name sortKey="Toyserkani, Navid Mohamadpour" sort="Toyserkani, Navid Mohamadpour" uniqKey="Toyserkani N" first="Navid Mohamadpour" last="Toyserkani">Navid Mohamadpour Toyserkani</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Plastic Surgery, Odense University Hospital, Odense, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Departments of Plastic Surgery, Odense University Hospital, Odense</wicri:regionArea><wicri:noRegion>Odense</wicri:noRegion></affiliation></author><author><name sortKey="Jensen, Charlotte Harken" sort="Jensen, Charlotte Harken" uniqKey="Jensen C" first="Charlotte Harken" last="Jensen">Charlotte Harken Jensen</name><affiliation wicri:level="1"><nlm:affiliation>The Danish Centre for Regenerative Medicine, Odense University Hospital, Odense, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>The Danish Centre for Regenerative Medicine, Odense University Hospital, Odense</wicri:regionArea><wicri:noRegion>Odense</wicri:noRegion></affiliation></author><author><name sortKey="Andersen, Ditte Caroline" sort="Andersen, Ditte Caroline" uniqKey="Andersen D" first="Ditte Caroline" last="Andersen">Ditte Caroline Andersen</name><affiliation wicri:level="1"><nlm:affiliation>The Danish Centre for Regenerative Medicine, Odense University Hospital, Odense, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>The Danish Centre for Regenerative Medicine, Odense University Hospital, Odense</wicri:regionArea><wicri:noRegion>Odense</wicri:noRegion></affiliation></author><author><name sortKey="Sheikh, S Ren Paludan" sort="Sheikh, S Ren Paludan" uniqKey="Sheikh S" first="S Ren Paludan" last="Sheikh">S Ren Paludan Sheikh</name><affiliation wicri:level="1"><nlm:affiliation>The Danish Centre for Regenerative Medicine, Odense University Hospital, Odense, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>The Danish Centre for Regenerative Medicine, Odense University Hospital, Odense</wicri:regionArea><wicri:noRegion>Odense</wicri:noRegion></affiliation></author><author><name sortKey="S Rensen, Jens Ahm" sort="S Rensen, Jens Ahm" uniqKey="S Rensen J" first="Jens Ahm" last="S Rensen">Jens Ahm S Rensen</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Plastic Surgery, Odense University Hospital, Odense, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Departments of Plastic Surgery, Odense University Hospital, Odense</wicri:regionArea><wicri:noRegion>Odense</wicri:noRegion></affiliation></author></analytic><series><title level="j">Stem cells translational medicine</title><idno type="ISSN">2157-6564</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Breast cancer-related lymphedema (BCRL) is a debilitating late complication with a lack of treatment opportunities. Recent studies have suggested that mesenchymal stromal cells can alleviate lymphedema. Herein, we report the results from the first human pilot study with freshly isolated adipose-derived regenerative cells (ADRC) for treating lymphedema with 6 months follow-up. Ten BCRL patients were included. ADRC was injected directly into the axillary region, which was combined with a scar-releasing fat graft procedure. Primary endpoints were change in arm volume. Secondary endpoints were change in patient reported outcome and safety. The study is registered with ClinicalTrials.gov (NCT02592213). During follow-up, a small volume reduction was noted but was not significant. Five patients reduced their use of conservative management. Patient-reported outcomes improved significantly over time. ADRCs were well tolerated and only minor transient adverse events related to liposuction were noted. In this pilot study, a single injection of ADRC improved lymphedema based on patient-reported outcome measures, and there were no serious adverse events in the 6 months follow-up period. In addition, half of the patients reduced their use of conservative management. ADRC therapy is a promising interventional therapy for alleviating lymphedema, but results need to be confirmed in randomized clinical trials. Stem Cells Translational Medicine 2017;6:1666-1672.</div></front></TEI><affiliations><list><country><li>Danemark</li></country></list><tree><country name="Danemark"><noRegion><name sortKey="Toyserkani, Navid Mohamadpour" sort="Toyserkani, Navid Mohamadpour" uniqKey="Toyserkani N" first="Navid Mohamadpour" last="Toyserkani">Navid Mohamadpour Toyserkani</name></noRegion><name sortKey="Andersen, Ditte Caroline" sort="Andersen, Ditte Caroline" uniqKey="Andersen D" first="Ditte Caroline" last="Andersen">Ditte Caroline Andersen</name><name sortKey="Jensen, Charlotte Harken" sort="Jensen, Charlotte Harken" uniqKey="Jensen C" first="Charlotte Harken" last="Jensen">Charlotte Harken Jensen</name><name sortKey="S Rensen, Jens Ahm" sort="S Rensen, Jens Ahm" uniqKey="S Rensen J" first="Jens Ahm" last="S Rensen">Jens Ahm S Rensen</name><name sortKey="Sheikh, S Ren Paludan" sort="Sheikh, S Ren Paludan" uniqKey="Sheikh S" first="S Ren Paludan" last="Sheikh">S Ren Paludan Sheikh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000057 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000057 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:28653440
|texte= Treatment of Breast Cancer-Related Lymphedema with Adipose-Derived Regenerative Cells and Fat Grafts: A Feasibility and Safety Study.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:28653440" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |